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List of Treatments for Depression

See what members are saying about depression treatments, the side effects to expect, and the drug basics.

All treatment information is medically reviewed · July 14, 2026

Abilify (Aripiprazole) for Major Depressive Disorder

Abilify (aripiprazole) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to help treat major depressive disorder in adults when taken with an antidepressant medication. Abilify is also FDA approved to treat other conditions, including schizophrenia and bipolar 1 disorder.

Abilify Asimtufii (Aripiprazole) for Bipolar 1 Disorder

Abilify Asimtufii (aripiprazole) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) as maintenance treatment used alone for adults with bipolar 1 disorder.

Abilify Maintena (Aripiprazole) for Bipolar 1 Disorder

Abilify Maintena (aripiprazole) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating adults with bipolar 1 disorder.

Aplenzin (Bupropion Hydrobromide) for Major Depressive Disorder

Aplenzin (bupropion hydrobromide) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating adults with major depressive disorder.

Bysanti (Milsaperidone) for Schizophrenia

Bysanti (milsaperidone) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating schizophrenia in adults.

Caplyta (Lumateperone) for Depression

Caplyta (lumateperone) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat major depressive disorder (MDD) and bipolar depression in adults.

Celexa (Citalopram) for Depression

Celexa (citalopram) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating adults with major depressive disorder (MDD).

Clozaril (Clozapine) for Schizophrenia

Clozaril (clozapine) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating adults with schizophrenia.

Cobenfy (Xanomeline and Trospium Chloride)

Cobenfy (xanomeline and trospium chloride) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat schizophrenia in adults.

Cymbalta (Duloxetine) for Major Depressive Disorder

Cymbalta (duloxetine) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating major depressive disorder in adults.

Drizalma Sprinkle (Duloxetine)

Drizalma Sprinkle (duloxetine) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating major depressive disorder in adults.

Emsam (Selegiline) for Major Depressive Disorder

Emsam (selegiline) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating adults with major depressive disorder.

Equetro (Carbamazepine) for Bipolar 1 Mania

Equetro (carbamazepine) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat adults with acute manic or mixed episodes linked to bipolar 1 disorder.

Fanapt (Iloperidone) for Schizophrenia

Fanapt (iloperidone) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating adults with schizophrenia.

Fetzima (Levomilnacipran) for Major Depressive Disorder

Fetzima (levomilnacipran) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating major depressive disorder in adults.

Forfivo XL (Bupropion Hydrochloride) for Major Depressive Disorder

Forfivo XL (bupropion hydrochloride) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating adults with major depressive disorder.

Geodon (Ziprasidone) for Bipolar 1 Disorder

Geodon (ziprasidone) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating adults with bipolar 1 disorder.

Invega (Paliperidone) for Schizophrenia

Invega (paliperidone) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat schizophrenia in adults and adolescents ages 12 to 17.

Lamictal (Lamotrigine) for Bipolar 1 Disorder

Lamictal (lamotrigine) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating adults with bipolar 1 disorder.

Latuda (Lurasidone) for Bipolar 1 Disorder

Latuda (lurasidone) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating adults and children ages 10 and older with depressive episodes associated with bipolar 1 disorder, also called bipolar depression. It's also FDA-approved to treat schizophrenia in adults and adolescents ages 13 and older.

Lexapro (Escitalopram) for Depression

Lexapro (escitalopram) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating major depressive disorder (MDD) in adults and children ages 12 and older.

Lybalvi (Olanzapine and Samidorphan) for Schizophrenia

Lybalvi (olanzapine and samidorphan) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat schizophrenia in adults.

Marplan (Isocarboxazid) for Depression

Marplan (isocarboxazid) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating depression in adults.

Nardil (Phenelzine) for Depression

Nardil (phenelzine sulfate) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating adults with certain kinds of depression.

Parnate (Tranylcypromine) for Depression

Parnate (tranylcypromine) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat adults with major depressive disorder (MDD) who have not responded to other antidepressant treatments.

Paxil (Paroxetine)

Paxil (paroxetine) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating adults with major depressive disorder (MDD).

Pristiq (Desvenlafaxine) for Major Depressive Disorder

Pristiq (desvenlafaxine) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating adults with major depressive disorder (MDD).

Prozac (Fluoxetine) for Depression

Prozac (fluoxetine) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat major depressive disorder (MDD) in adults and children ages 8 and older.

Remeron (Mirtazapine) for Depression

Remeron (mirtazapine) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat adults with major depressive disorder (MDD).

Rexulti (Brexpiprazole) for Major Depressive Disorder

Rexulti (brexpiprazole) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat major depressive disorder (MDD) in adults.

Risperdal (Risperidone)

Risperdal (risperidone) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating bipolar 1 disorder in adults and children ages 10 to 17 years.

Risperdal Consta (Risperidone)

Risperdal Consta (risperidone) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to help maintain treatment in adults with bipolar 1 disorder. It can be used alone or with other medicines like lithium or valproate.

Rykindo (Risperidone) for Schizophrenia

Rykindo (risperidone) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating schizophrenia in adults.

Saphris (Asenapine) for Schizophrenia

Saphris (asenapine) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating adults with schizophrenia.

Seroquel XR (Quetiapine) for Depression

Seroquel XR (quetiapine) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) as an add-on treatment to antidepressants for adults with major depressive disorder (MDD).

Spravato (Esketamine)

Spravato (esketamine) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat adults with treatment-resistant depression (TRD). It can also be used with an oral antidepressant to treat depressive symptoms in adults with major depressive disorder (MDD) who have acute suicidal thoughts or actions.

Symbyax (Olanzapine/Fluoxetine) for Depression

Symbyax (olanzapine/fluoxetine) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) in adults to treat treatment-resistant depression, which is major depressive disorder (MDD) that has not improved after two different antidepressant treatments.

Trintellix (Vortioxetine) for Depression

Trintellix (vortioxetine) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat adults with major depressive disorder.

Viibryd (Vilazodone) for Depression

Viibryd (vilazodone) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat adults with major depressive disorder (MDD).

Vraylar (Cariprazine) for Depression

Vraylar (cariprazine) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat depressive episodes associated with bipolar 1 disorder (bipolar depression) in adults. It is also used with other antidepressants to treat major depressive disorder (MDD) in adults.

Wellbutrin SR (Bupropion Hydrochloride) for Depression

Wellbutrin SR (bupropion hydrochloride) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat adults with major depressive disorder.

Wellbutrin XL (Bupropion Hydrochloride) for Depression

Wellbutrin XL (bupropion hydrochloride) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating adults with major depressive disorder (MDD).

Zoloft (Sertraline) for Depression

Zoloft (sertraline) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat adults with major depressive disorder (MDD).

Zurzuvae (Zuranolone) for Postpartum Depression

Zurzuvae (zuranolone) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat postpartum depression (PPD) in adults.

Zyprexa (Olanzapine) for Bipolar 1 Disorder

Zyprexa (olanzapine) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat acute manic or mixed episodes associated with bipolar 1 disorder in adults and adolescents ages 13 to 17 years, and for maintenance treatment of bipolar 1 disorder in adults.

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