Zurzuvae (Zuranolone) for Depression

Overview
Zurzuvae is approved by the U.S. Food and Drug Administration (FDA) to treat postpartum depression in adults. It’s prescribed for people experiencing depression after childbirth. Zurzuvae can be taken by itself or alongside other antidepressants. It’s also known by its drug name, zuranolone.

Zurzuvae is a neuroactive steroid that acts as a positive modulator of gamma-aminobutyric acid (GABA) A receptors in the brain. It is believed to help restore balance to brain activity, alleviating symptoms of depression.

How is it taken?
Zurzuvae comes in capsule form and is usually taken once a day in the evening for 14 days. It should be taken with a meal that includes fat to help your body absorb the medication. Always follow your healthcare provider’s instructions when taking Zurzuvae.

What are the side effects?
Common side effects of Zurzuvae include somnolence (drowsiness), dizziness, diarrhea, fatigue, nasopharyngitis (common cold), and urinary tract infections.

Rare but serious side effects may include severe central nervous system (CNS) depression (such as confusion or profound drowsiness), suicidal thoughts or behaviors, and potential harm to a fetus if taken during pregnancy. 

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Label: Zurzuvae — Zuranolone Capsule — DailyMed