Wellbutrin XL (Bupropion Hydrochloride) for Depression

Overview

Wellbutrin XL is approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD) and for the prevention of seasonal affective disorder (SAD). For individuals with MDD, the need for maintenance treatment should be periodically reassessed. Wellbutrin XL carries a boxed warning regarding increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults. Wellbutrin XL is also known by its drug name, bupropion hydrochloride.

Bupropion hydrochloride is an aminoketone antidepressant. It works by increasing the levels of dopamine and norepinephrine — two neurotransmitters involved in regulating mood. These chemical messengers are thought to help relieve symptoms of depression.

How do I take it?

Prescribing information states that Wellbutrin XL is taken by mouth as an extended-release tablet once daily. For MDD, the starting dose may be increased after four days. Wellbutrin XL should be taken exactly as prescribed by a healthcare provider.

Side effects

Common side effects of Wellbutrin XL include xerostomia (dry mouth), nausea, insomnia, vertigo (dizziness), pharyngitis (sore throat), abdominal pain, agitation, anxiety, tremor, palpitations (rapid heartbeat), hyperhidrosis (sweating), tinnitus (ringing in the ears), myalgia (muscle pain), anorexia (loss of appetite), increased urinary frequency, and rash.

Rare but serious side effects may include seizures, hypertension (high blood pressure), manic or hypomanic episodes, psychosis, hallucinations, delusions, paranoia, suicidal ideation (thoughts of suicide), and angle-closure glaucoma (a rapid, painful increase in eye pressure). Neuropsychiatric reactions have been reported during smoking cessation efforts using bupropion.

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Label: Wellbutrin XL — Bupropion Hydrochloride Tablet, Extended Release — DailyMed