Forfivo XL (Bupropion Hydrochloride) for Depression

Overview

Forfivo XL is approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD) in adults. Forfivo XL is not recommended as a starting treatment. It is intended for individuals who are already tolerating a lower dose of bupropion and require an increased dosage. Forfivo XL is also known by its drug name, bupropion hydrochloride.

Bupropion hydrochloride is an aminoketone antidepressant. It works by affecting the brain’s levels of dopamine and norepinephrine, two chemical messengers involved in regulating mood. These effects are believed to relieve symptoms of depression.

How do I take it?

Prescribing information states that Forfivo XL is taken by mouth as one extended-release tablet once daily, with or without food. The tablet must be swallowed whole—do not chew, divide, or crush it. 

Forfivo XL should not be used as an initial treatment. It is designed for individuals who have already been receiving another bupropion formulation for at least two weeks and require a higher dose. 

This medication should be taken exactly as prescribed by a healthcare provider.

Side effects

Common side effects of Forfivo XL include xerostomia (dry mouth), nausea, insomnia, vertigo (dizziness), pharyngitis (sore throat), abdominal pain, agitation, anxiety, tremor, palpitations (rapid heartbeat), hyperhidrosis (sweating), tinnitus (ringing in the ears), myalgia (muscle pain), anorexia (loss of appetite), increased urinary frequency, and rash.

Rare but serious side effects may include seizures, hypertension (high blood pressure), manic or hypomanic episodes, hallucinations, paranoia, delusions, suicidal ideation (thoughts of suicide), psychosis, and angle-closure glaucoma (a sudden increase in eye pressure that can lead to vision loss).

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Label: Forfivo XL — Bupropion Hydrochloride Tablet, Film Coated, Extended Release — DailyMed