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List of Treatments for Depression

Below is a listing of treatments and therapies for depression. Click on one to read more information or connect with others currently using it.

Abilify (Aripiprazole)

Overview
Abilify is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia, the acute treatment of manic and mixed episodes associated with bipolar 1 disorder, and as an adjunctive…

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Abilify Asimtufii (Aripiprazole)

Overview
Abilify Asimtufii is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia in adults and as a maintenance monotherapy (single-drug treatment) for bipolar 1 disorder in adults…

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Abilify Maintena (Aripiprazole)

Overview
Abilify Maintena is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia and the maintenance monotherapy (single-drug treatment) of bipolar 1 disorder in adults. This…

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Adderall (Amphetamine/Dextroamphetamine)

Overview
Adderall is a prescription drug approved by the Food and Drug Administration (FDA) to treat attention deficit disorder with hyperactivity. Adderall is sometimes prescribed to treat depression. Since the FDA has… read more

Amitriptyline

Overview

Amitriptyline is approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder. Use in children and adolescents under 18 is generally not recommended due to increased risk…

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Aplenzin (Bupropion Hydrobromide)

Overview

Aplenzin is approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD). Individuals may be prescribed Aplenzin for short-term or long-term treatment depending on…

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Ativan (Lorazepam)

Overview
Ativan is a prescription drug approved by the Food and Drug Administration (FDA) to treat anxiety. Ativan is also known by its drug name, Lorazepam.

Ativan is an anxiolytic (antianxiety medication) of the… read more

Caplyta (Lumateperone)

Overview
Caplyta is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia and for use as an adjunctive therapy with antidepressants for major depressive disorder (MDD) in adults. It is…

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Carbatrol (Carbamazepine)

Overview
Carbatrol is a prescription drug approved by the Food and Drug Administration (FDA) to treat trigeminal neuralgia and some types of seizures. Carbatrol is sometimes prescribed to treat certain types of… read more

Clozaril (Clozapine)

Overview
Clozaril is a prescription drug approved by the Food and Drug Administration (FDA) for treatment-resistant schizophrenia. Clozaril is sometimes prescribed to treat depression that has failed to respond to… read more

Cymbalta (Duloxetine)

Overview

Cymbalta is a prescription drug approved by the Food and Drug Administration (FDA) to treat depression, anxiety, diabetic peripheral neuropathy, fibromyalgia, and chronic musculoskeletal pain. Cymbalta is also…

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Depakene (Valproic Acid) for Depression

The Depakene FS brand name has been discontinued in the U.S. for reasons unrelated to safety or efficacy. Other brand names or generic alternatives may be available. If you’re currently taking this medication, talk to… read more

Dexedrine (Dextroamphetamine)

Overview
Dexedrine is a prescription drug approved by the Food and Drug Administration (FDA) to treat narcolepsy and attention deficit disorder with hyperactivity. Dexedrine is sometimes prescribed to treat depression.… read more

Doxepin

Overview

Doxepin is approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD). It is not recommended for children under 18 due to an increased risk of suicidal thoughts…

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Drizalma Sprinkle (Duloxetine)

Overview

Drizalma Sprinkle is approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD) in adults.Drizalma Sprinkle is also known by its drug name, duloxetine.

Drizalma…

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Elavil (Amitriptyline)

The Elavil brand name has been discontinued in the U.S. for reasons unrelated to safety or efficacy. Other brand names or generic alternatives may be available. If you’re currently taking this medication, talk to your…

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Electroconvulsive therapy (ECT)

Overview
Electroconvulsive therapy (ECT) is a medical procedure sometimes used to treat severe cases of depression that don’t respond to therapy or medication. ECT may be used to treat depression characterized by… read more

Emsam (Selegiline)

Overview
Emsam is a prescription drug approved by the Food and Drug Administration (FDA) to treat major depressive disorder in people 12 years and older. Emsam is also known by its drug name, Selegiline.

Emsam is an… read more

Eskalith (Lithium)

The Eskalith brand name has been discontinued in the U.S. Other brand name or generic alternatives may be available.

Overview

Eskalith is a prescription drug approved by the Food and Drug Administration (FDA) to treat…

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Fetzima (Levomilnacipran)

Overview
Fetzima is a prescription drug approved by the Food and Drug Administration (FDA) to treat major depressive disorder. Fetzima is also known by its drug name, Levomilnacipran.

Fetzima is an antidepressant of… read more

Forfivo XL (Bupropion Hydrochloride)

Overview

Forfivo XL is approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD) in adults. Forfivo XL is not recommended as a starting treatment. It is intended for…

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Geodon (Ziprasidone)

Overview
Geodon is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia in adults, and for the treatment of manic or mixed episodes associated with bipolar 1 disorder. For bipolar 1…

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Ketamine

Overview
Ketamine is a prescription drug approved by the Food and Drug Administration (FDA) to be used an an anesthetic. Ketamine is sometimes used to treat depression. Since the FDA has not approved Ketamine… read more

Klonopin (Clonazepam)

Overview
Klonopin is a prescription drug approved by the Food and Drug Administration (FDA) to treat seizures and panic disorder. Klonopin is also known by its drug name, Clonazepam.

Klonopin is an anxiolytic… read more

Lamictal (Lamotrigine)

Overview
Lamictal is a prescription drug approved by the Food and Drug Administration (FDA) to treat epilepsy and bipolar disorder. Lamictal is sometimes prescribed for people with major depressive disorder when… read more

Latuda (Lurasidone)

Overview
Latuda is a prescription drug approved by the Food and Drug Administration (FDA) to treat schizophrenia and depressive episodes associated with bipolar depression. Latuda is also known by its drug name,… read more

Lybalvi (Olanzapine and Samidorphan)

Overview
Lybalvi is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat schizophrenia and bipolar 1 disorder in adults. Lybalvi may be prescribed alone for short periods to treat… read more

Marplan (Isocarboxazid)

Overview
Marplan is a prescription drug approved by the Food and Drug Administration (FDA) to treat depression when other antidepressants have failed. Marplan is also known by its drug name, Isocarboxazid.

Marplan… read more

Nardil (Phenelzine)

Overview
Nardil is a prescription drug approved by the Food and Drug Administration (FDA) to treat certain types of depression when other antidepressants have failed. Nardil is also known by its drug name, Phenelzine.… read more

Neurontin (Gabapentin)

Overview
Neurontin is a prescription drug approved by the Food and Drug Administration (FDA) to treat postherpetic neuralgia and some types of seizures. Neurontin is sometimes prescribed to treat depression and anxiety.… read more

Oleptro (Trazodone) for Depression

The Oleptro brand name has been discontinued in the U.S. for reasons unrelated to safety or efficacy. Other brand names or generic alternatives may be available. If you’re currently taking this medication, talk to your… read more

Parnate (Tranylcypromine)

Overview
Parnate is a prescription drug approved by the Food and Drug Administration (FDA) to treat major depressive episodes in adults under close medical supervision. Parnate is also known by its drug name,… read more

ProlivRx for Depression

Overview
ProlivRx is a prescription-only neuromodulation device approved by the U.S. Food and Drug Administration (FDA) as an adjunctive (add-on) treatment for adults with major depressive disorder (MDD) who have not had…

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Provigil (Modafinil)

Overview
Provigil is a prescription medication approved by the Food and Drug Administration (FDA) for the treatment of excessive sleepiness associated with narcolepsy, obstructive sleep apnea, and shift work disorder.… read more

Psychotherapy

Overview
Psychotherapy, also known simply as therapy, is a common treatment for depression. Therapy may be used to treat depression on its own or in combination with antidepressant medications.

What does it involve?… read more

Remeron (Mirtazapine)

Overview
Remeron is a prescription drug approved by the Food and Drug Administration (FDA) to treat depression in adults. Remeron is also referred to by its drug name, Mirtazapine.

Remeron is an atypical… read more

Rexulti (Brexpiprazole)

Overview
Rexulti is a prescription drug approved by the Food and Drug Administration (FDA) as an adjunctive (add-on) therapy to antidepressants for treating major depressive disorder. Rexulti is also known by its drug… read more

Risperdal (Risperidone)

Overview
Risperdal is a prescription drug approved by the Food and Drug Administration (FDA) for the treatment of manic or mixed episodes associated with bipolar I disorder. Risperdal is also known by its drug name,… read more

Risperdal Consta (Risperidone)

Overview
Risperdal Consta is a prescription drug approved by the Food and Drug Administration (FDA) for maintenance treatment of bipolar I disorder. Risperdal Consta is also known by its drug name, Risperidone.… read more

Ritalin (Methylphenidate)

Overview
Ritalin is a prescription drug approved by the Food and Drug Administration (FDA) to treat narcolepsy and attention deficit disorders. Ritalin is sometimes prescribed to treat depression. Since the FDA has not… read more

Saphris (Asenapine)

Overview
Saphris is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia in adults and for the treatment of bipolar 1 disorder in both adults and children aged 10 to 17. For bipolar 1…

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Savella (Milnacipran)

Overview
Savella is a prescription drug approved by the Food and Drug Administration (FDA) to treat fibromyalgia. Savella is sometimes prescribed to treat depression. Since the FDA has not approved Savella specifically… read more

Seroquel XR (Quetiapine)

Overview
Seroquel XR is a prescription drug approved by the Food and Drug Administration (FDA) for the treatment of bipolar disorder and some types of depression. Seroquel XR is also known by its drug name, Quetiapine.… read more

Spravato (Esketamine)

Overview
Spravato is a prescription drug approved by the U.S. Food and Drug Administration (FDA) for the treatment of adults with treatment-resistant depression (TRD), either alone or in combination with an oral…

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Tegretol (Carbamazepine)

Overview
Tegretol is a prescription drug approved by the Food and Drug Administration (FDA) to treat trigeminal neuralgia and some types of seizures. Tegretol is sometimes prescribed to treat certain types of… read more

Topamax (Topiramate)

Overview
Topamax is a prescription drug approved by the Food and Drug Administration (FDA) to treat epilepsy and migraines. Topamax is sometimes prescribed to treat depression. Since the FDA has not approved Topamax… read more

Transcranial magnetic stimulation (TMS)

Overview
Transcranial magnetic stimulation (TMS) is a medical procedure sometimes used to treat severe cases of depression that don’t respond to therapy or medication. TMS may also be considered as treatment for… read more

Trazodone

Overview

Trazodone is approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD). It is not recommended for children under 18 due to an increased risk of suicidal thoughts…

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Trintellix (Vortioxetine)

Overview
Trintellix is a prescription drug approved by the Food and Drug Administration (FDA) to treat major depressive disorder. Trintellix is also referred to by its drug name, Vortioxetine. Trintellix was previously… read more

Valium (Diazepam)

Overview
Valium is a prescription drug approved by the Food and Drug Administration (FDA) to treat anxiety. Valium is also known by its drug name, Diazepam.

Valium is an anxiolytic (antianxiety medication) of the… read more

Viibryd (Vilazodone)

Overview
Viibryd is a prescription drug approved by the Food and Drug Administration (FDA) to treat major depressive disorder. Viibryd is also referred to by its drug name, Vilazodone.

Viibryd is an atypical… read more

Vivactil (Protriptyline) for Depression

The Vivactil brand name has been discontinued in the U.S. for reasons unrelated to safety or efficacy. Other brand names or generic alternatives may be available. If you’re currently taking this medication, talk to your… read more

Vraylar (Cariprazine)

Overview
Vraylar is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia in adults. It is also approved for the acute treatment of manic or mixed episodes and depressive episodes…

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Wellbutrin (Bupropion)

The Wellbutrin brand name has been discontinued in the U.S. Other brand name or generic alternatives may be available.

Overview

Wellbutrin is a prescription drug approved by the Food and Drug Administration (FDA) to…

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Wellbutrin SR (Bupropion Hydrochloride)

Overview

Wellbutrin SR is approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD). It is intended for use in adults and is not approved for children. Wellbutrin SR…

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Wellbutrin XL (Bupropion Hydrochloride)

Overview

Wellbutrin XL is approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD) and for the prevention of seasonal affective disorder (SAD). For individuals with MDD…

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Xanax (Alprazolam)

Overview
Xanax is a prescription drug approved by the Food and Drug Administration (FDA) to treat anxiety. Xanax is also known by its drug name, Alprazolam.

Xanax is an anxiolytic (antianxiety medication) of the… read more

Zoloft (Sertraline)

Overview
Zoloft is a prescription drug approved by the Food and Drug Administration (FDA) to treat major depressive disorder in adults. Zoloft is also known by its drug name, Sertraline.

Zoloft is an antidepressant… read more

Zulresso (Brexanolone)

The Zulresso brand name has been discontinued in the U.S.

Overview
Zulresso is approved by the U.S. Food and Drug Administration (FDA) for the treatment of postpartum depression (PPD) in people 15 and older. As of July…

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Zurzuvae (Zuranolone)

Overview
Zurzuvae is approved by the U.S. Food and Drug Administration (FDA) to treat postpartum depression in adults. It’s prescribed for people experiencing depression after childbirth. Zurzuvae can be taken by itself…

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Zyprexa (Olanzapine)

Overview
Zyprexa is a prescription drug approved by the Food and Drug Administration (FDA) for the treatment of schizophrenia. Zyprexa is sometimes prescribed to treat depression that has failed to respond to… read more

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