Wellbutrin SR (Bupropion Hydrochloride) for Depression

Overview

Wellbutrin SR is approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD). It is intended for use in adults and is not approved for children. Wellbutrin SR carries a boxed warning due to the increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults. Treatment should be periodically reassessed to determine continued need and appropriate dosage. Wellbutrin SR is also known by its drug name, bupropion hydrochloride.

Bupropion hydrochloride is an aminoketone antidepressant. It works by increasing levels of dopamine and norepinephrine in the brain — neurotransmitters believed to help regulate mood and relieve depressive symptoms.

How do I take it?

Prescribing information states that Wellbutrin SR is taken by mouth in sustained-release tablet form. After three days on the initial starting dose, the dose may be increased. Wellbutrin SR should be taken exactly as prescribed by a healthcare provider.

Side effects

Common side effects of Wellbutrin SR include cephalalgia (headache), xerostomia (dry mouth), nausea, insomnia, vertigo (dizziness), pharyngitis (sore throat), constipation, agitation, anxiety, abdominal pain, tinnitus (ringing in the ears), tremor, palpitations (rapid heartbeat), myalgia (muscle pain), hyperhidrosis (sweating), rash, and anorexia (loss of appetite).

Rare but serious side effects may include seizures, hypertension (high blood pressure), mania or hypomania, hallucinations, delusions, psychosis, suicidal ideation (thoughts of suicide), angle-closure glaucoma (a sudden increase in eye pressure), and neuropsychiatric reactions during smoking cessation such as aggression, paranoia, or homicidal ideation.

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Label: Wellbutrin SR — Bupropion Hydrochloride Tablet, Film Coated — DailyMed