Connect with others who understand.

  •   Learn from expert-reviewed resources
  •   Real advice from people who’ve been there
  •   People who understand what you’re going through
Sign Up Log In
Powered By

Depression Symptoms: Physical, Emotional, and Cognitive Signs

Medically reviewed by Anna Kravtsov, D.O.
Updated on October 15, 2026

Key Takeaways

  • Depression is a complex condition that can look different for everyone, affecting not just mood but the whole body and brain function.
  • The DSM-5-TR outlines nine possible symptoms of depression, including low mood, loss of interest, sleep changes, fatigue, and difficulty concentrating, with at least five needed for a diagnosis. Depression can also show up in physical ways, like changes in appetite and weight, low energy, headaches, and even effects on sex drive.
  • If you or someone you know is experiencing symptoms of depression, reaching out to a healthcare provider is a helpful first step, and if you or someone you know needs immediate support, you can contact the 988 Suicide and Crisis Lifeline by calling or texting 988.
  • View all takeaways

Depression can look different for different people. The symptoms go beyond “feeling blue” or low energy. Depression can affect the whole body. It can also lead to real changes in brain function.

There are various types of depression, and your symptoms may shift over time. Understanding the full potential impact of depression can help you better manage it.

What Symptoms Qualify as Depression?

The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR) lists nine possible symptoms for depression. For a formal depression diagnosis, someone must have at least one of the following symptoms for at least two weeks:

🗳️ What type of depression symptom do you most commonly experience?
Physical symptoms, such as fatigue or sleep changes
Emotional symptoms, such as sadness or irritability
Thinking problems, such as trouble concentrating
Something else/not sure
  • Depressed mood most of the day, nearly every day, as reported by the person or their loved ones
  • Significant loss of interest or pleasure in all, or almost all, activities most of the day, nearly every day

A depression diagnosis also requires the person to have at least three to four of the following, for a total of five or more depression symptoms:

  • Significant weight loss or gain that isn’t on purpose, or a major change in appetite
  • Trouble sleeping or sleeping too much almost every day
  • Being visibly agitated, restless, or physically slower
  • Daily lack of energy
  • Feeling consistently worthless or overly guilty
  • Trouble concentrating or thinking clearly daily
  • Preoccupation with death or suicidal thoughts or plans

For a diagnosis of major depressive disorder, these symptoms must also cause significant distress or make it harder to function in daily life. A healthcare provider will also consider whether the symptoms could be caused by substances, medications, another medical condition, or bipolar disorder.

Note: If you or someone you know needs help, you can contact the 988 Suicide & Crisis Lifeline by calling or texting 988 or chatting online.

Physical Symptoms of Depression

Fatigue is a common symptom of depression. Fatigue may stem from a sleep disorder, such as insomnia, or other sleep problems. Some people with depression feel exhausted even after a full night’s sleep.

In many cases, depression includes sleeping too much. However, that doesn’t necessarily mean having more energy when awake. Someone who is depressed may tend to move slowly, as if they’re in slow motion.

However, agitation is another possible sign of depression. Others may notice the person can’t sit still, paces, or seems restless.

Depression may also be associated with headaches, cramps, digestive problems, or aches and pains with no obvious other cause. Appetite and weight changes are common and could be related to depression medication side effects or the depression itself.

For adults, a 5 percent loss or gain of body weight is considered significant if it happens within one month. Children with depression may not lose weight. Instead, they might not grow as expected.

Depression often reduces libido, or sex drive, too. Many antidepressants can lower your interest in sex or cause sexual dysfunction, such as difficulty getting an erection or having an orgasm. Sexual problems related to antidepressant use may affect up to 65 percent of those being treated for depression.

Emotional Symptoms of Depression

The main symptom of depression is low mood. Mood problems can manifest as sadness or feelings of emptiness. Depression can cause you to feel hopeless or pessimistic, viewing everything in a negative light.

Depression also makes some people more irritable or easily frustrated, especially in the case of kids or teens. People may feel guilty or worthless, and their self-confidence may take a hit.

Hobbies and interests that once excited them can fall by the wayside when depression sets in. Lack of motivation and drive are typical outward signs of depression.

How Depression Impacts Behaviors

People living with depression may withdraw from social situations. For people with seasonal affective disorder, this may feel like “hibernating” during the winter months, when they may sleep more, have less energy, and spend more time at home. SAD is a type of depression that follows a repeating seasonal pattern. It most often begins in the fall or winter and improves in the spring or summer, although some people have the opposite pattern. Rainy weather or spending time in a dark room may affect mood, but these factors alone do not mean someone has SAD.

In some cases, depression can increase the likelihood of negative outcomes in areas of a person’s life. Some people may experience difficulties functioning at work, lower quality of life, worsening health problems, and substance use.

A depressive episode can also be part of bipolar disorder, which may include periods of depression and mania. Mania is a mood episode with emotional highs, including hyperactivity and euphoria. During manic episodes, risky behaviors, such as gambling, are more likely.

Cognitive Symptoms of Depression

Depression is directly tied to brain function. It can significantly affect thinking and decision-making.

Some people have trouble concentrating or focusing at work. Others may feel overwhelmed by daily decisions they used to handle easily.

Psychotic Symptoms

Psychosis can happen if someone has a break in their sense of reality during an episode of severe depression. Two main types of psychotic symptoms may affect people with depression: delusions and hallucinations.

Delusions are strong false beliefs that people hold on to even when evidence suggests they aren’t true. Hallucinations involve hearing, seeing, touching, smelling, or tasting things that aren’t there.

During a delusion, the person may appear to be paranoid and suspicious. They may overthink or misinterpret what another person said or did.

People who have psychotic symptoms often display a sudden decline in self-care. They may spend more time alone and stop grooming and maintaining their personal hygiene.

At What Age Do Symptoms Appear?

Different types of depression typically start at different ages. Major depressive disorder can start at any age. It often starts during the early 30s. The first signs can appear earlier, in adolescence or early adulthood.

Bipolar disorder usually begins between the teens and early 20s. SAD is most common in young adults between the ages of 18 and 30.

Do Depression Symptoms Go Away?

Major depressive episodes can be temporary or long-lasting. Symptoms can improve with treatment, such as psychotherapy and antidepressants.

Still, many people with depression do not receive treatment. Recent data show that about 39 percent of adults with a major depressive episode in the U.S. did not receive mental health treatment. Among adolescents with a major depressive episode, about 60 percent did not receive treatment.

Overall, depressive episodes can vary in length. Some people have chronic depression — lasting two years or more. People with chronic depression may need to try several different treatment approaches to find one that works for them.

In addition, about 30 percent of major depression is resistant to treatment. If antidepressants have failed, there’s still hope. Other treatments, such as transcranial magnetic stimulation and therapeutic approaches, may be more effective. It’s important to continue seeking help and support to get depression symptoms under control.

Share this article
A MyDepressionTeam Member

You are not alone here. We understand completely. Let us lift you up. Where have you looked to find treatment? Maybe we can help by suggesting some places. My heart goes out to you. Lifting you… read more

All updates must be accompanied by text or a picture.

We'd love to hear from you! Please share your name and email to post and read comments.

You'll also get the latest articles directly to your inbox.

Subscriber Photo Subscriber Photo Subscriber Photo
242,384 members
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service.
Privacy Policy • Terms of Use
All updates must be accompanied by text or a picture.

Subscribe now to ask your question, get answers, and stay up to date on the latest articles.

Get updates directly to your inbox.

Subscriber Photo Subscriber Photo Subscriber Photo
242,384 members
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service.
Privacy Policy • Terms of Use

Does Depression ever go away

A MyDepressionTeam Member · 21 answers
View Answers
Continue with Facebook
Continue with Google
By joining, you accept our Terms of Use, and acknowledge our collection, sharing, and use of your data in accordance with our Health Data and Privacy policies.
Already a member? Log In

Thank you for subscribing!

Become a member to get even more

See answer