I haven't had any problems with taking it. I normaly take it in the morning before eating but sometimes I forget and take it midday.

I take Wellbutrin with my Effexor in the morning before breakfast. I havent had any problems with appetite or anything while on it. If its affecting you that much, definitely talk to your doctor.

Have never taken it but if it is affecting your appetite that badly then I would talk to your doctor again.