I've been taking it for about 3 weeks, and in that time I've been experiencing loss of appetite. I have to force myself to eat and if it's not something I like, I gag on it.
I haven't had any problems with taking it. I normaly take it in the morning before eating but sometimes I forget and take it midday.
I take Wellbutrin with my Effexor in the morning before breakfast. I havent had any problems with appetite or anything while on it. If its affecting you that much, definitely talk to your doctor.
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