I'm on 300 mg effexor daily have been for at least 9 years. No weight gain, but I'm sure I'm ready for a med change.

I have a problem with ambition. Indecisive and forgetful. Been on 75mg for a yr. It helps with anxiety but depression I still have ups and downs every month.

I am also on 300mg Effexor and have slowly gained weight over the years, but I was also diagnosed with Hypothyroidism a few years ago which can also cause weight gain---I had no idea I had it. Worth the check.

Unfortunately some meds do make you gain weight
I ballooned on quitiapein 50mg which is a very low dose
My Vensir XL 325mg has not affected my weight at all
Hugh