Trazodone for Depression

Overview

Trazodone is approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD). It is not recommended for children under 18 due to an increased risk of suicidal thoughts and behaviors, although a doctor may prescribe it in limited circumstances. Individuals taking trazodone should be closely monitored during dose adjustments and the early phases of treatment.

Trazodone is a serotonin modulator. It works by increasing levels of serotonin, a neurotransmitter that helps maintain emotional balance. This action is thought to improve mood and alleviate symptoms of depression.

How do I take it?

Prescribing information states that trazodone is taken by mouth in tablet form, usually with a meal or light snack two or more times daily. Tablets should be swallowed whole or broken in half at the scored line. Treatment generally begins with a low dose, which may be increased every three to four days as needed. Once the condition is controlled, the dose may be gradually reduced. Trazodone should be taken exactly as prescribed by a healthcare provider. 

Side effects

Common side effects of trazodone include nausea, vomiting, diarrhea, constipation, appetite or weight changes, asthenia (weakness or tiredness), anxiety, vertigo (dizziness or lightheadedness), nightmares, myalgia (muscle pain), xerostomia (dry mouth), rash, sexual dysfunction in males (including decreased libido, erectile dysfunction, or delayed ejaculation), sexual dysfunction in females (including decreased libido or anorgasmia), tremor (uncontrollable shaking), nasal congestion, and eye irritation (tired, red, or itchy eyes).

Rare but serious side effects may include angina (chest pain), arrhythmia (fast, pounding, or irregular heartbeat), coma (loss of consciousness), serotonin syndrome (fever, confusion, muscle stiffness, agitation, hallucinations, and vomiting), syncope (fainting), seizures, dyspnea (shortness of breath), coagulopathy (unusual bruising or bleeding), epistaxis (nosebleeds), petechiae (small red or purple spots on the skin), priapism (erection lasting more than six hours), headache, cognitive impairment (problems with thinking or memory), and ataxia (problems with coordination).

For more information about this treatment, visit:

Trazodone — MedlinePlus