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Real members of MyDepressionTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyDepressionTeam Member asked a question 💭
Knoxville, TN

Taking Wellbutrin and now Caplyta

March 19
 · 
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A MyDepressionTeam Member

Fatigue is my worst symptom with MS, and the depression doesn't help. I break up tasks into smaller increments to make it easier. It may take me all day to cook dinner, but with rest breaks I manage.

March 19
MyDepressionTeam

Why do you feel so tired with no motivation while taking Wellbutrin and Caplyta?

Fatigue and lack of motivation are common symptoms of depression itself, not just side effects of medication. Depression can drain your physical energy and alter your brain's reward system, making even simple tasks feel overwhelming. Many Show Full Answer

Why do you feel so tired with no motivation while taking Wellbutrin and Caplyta?

Fatigue and lack of motivation are common symptoms of depression itself, not just side effects of medication. Depression can drain your physical energy and alter your brain's reward system, making even simple tasks feel overwhelming. Many people with depression experience persistent exhaustion regardless of how much they sleep.

However, antidepressant medications can also contribute to feeling tired or sleepy, especially at higher doses or when starting a new medication like Caplyta. Since you've recently added Caplyta to your treatment, this could be affecting your energy levels.

It's important to talk with your doctor about how you're feeling. They can help determine whether your fatigue is primarily from depression symptoms or medication side effects, and adjust your treatment plan accordingly. Never change your medication without your doctor's supervision.

In the meantime, some strategies that might help include:
- Breaking tasks into smaller, manageable steps
- Setting small, achievable goals
- Establishing simple daily routines
- Gentle movement or short walks when possible
- Being patient with yourself as your body adjusts

Remember, feeling tired and unmotivated isn't a personal failure—it's a real symptom of your condition that deserves proper medical attention.

March 19

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