Provigil (Modafinil) for Depression | MyDepressionTeam

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Provigil is a prescription medication approved by the Food and Drug Administration (FDA) for the treatment of excessive sleepiness associated with narcolepsy, obstructive sleep apnea, and shift work disorder. In cases of depression, Provigil may be prescribed off-label to treat fatigue and sleepiness. Provigil may be referred to by its drug name, Modafinil.

Provigil is a eugeroic, or wakefulness-promoting drug. Provigil is believed to work by altering the levels of neurotransmitters in the brain.

How do I take it?
Provigil should be taken exactly as directed by your doctor.

Provigil is available in tablet form.

Side effects
The FDA-approved label for Provigil lists common side effects including headache, dizziness, nervousness, anxiety, back pain, cold symptoms, nausea, upset stomach, and diarrhea.

Rare but serious side effects listed for Provigil can include severe rash, hypersensitivity and allergic reactions, and psychiatric symptoms such as psychosis, depression, or mania.

For more details about this treatment, visit:

Provigil highlights of prescribing information (PDF) – Teva

Modafinil reduces depression's severity when taken with antidepressants – Science Daily

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