Depakene (Valproic acid) for Depression | MyDepressionTeam

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The Depakene brand name has been discontinued in the U.S. Generic alternatives may be available.


Depakene is a prescription drug approved by the Food and Drug Administration (FDA) to treat epilepsy. Depakene is sometimes prescribed to treat depressive symptoms in people with bipolar disorder. Since the FDA has not approved Depakene specifically for this usage, it is considered “off-label.” Depakene is also known by its drug name, Valproic acid. Depakene is an anticonvulsant. In cases of depression, Depakene works as a mood stabilizer. Depakene is believed to work by changing the balance of neurotransmitters in the brain.

How do I take it?

Depakene should be taken as prescribed. Depakene comes in capsule form.

Side effects

The FDA-approved label for Depakene lists common side effects including dizziness, drowsiness, weakness, blurred or double vision, ringing in the ears (tinnitus), unsteadiness, tremors, hair loss, strange taste in the mouth, diarrhea, constipation, and upset stomach. Rare but serious side effects listed for Depakene include liver damage, pancreatitis, and suicidal thoughts.

For more details about this treatment, visit:

Depakene – RxList

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